What gets published on PTEN and nerve regeneration, and what each item changes. Papers, clinical trial records and structural depositions, dated and linked.
How this page works
Every entry reports someone else's published work and links to the source, so any claim here can be checked by following the link. Where a line is our reading rather than the source's, it is marked separately.
Entries are not edited after publication. A correction is added as its own dated entry.
2026-09-09
A trial is now powered on retinal ganglion cell layer thinning as its primary endpoint
The NADIR trial (NCT07808333), a phase 2a study of oral nicotinamide, lists annualised macular ganglion cell inner plexiform layer thinning as its primary endpoint, measured across four assessments over twelve months under a pre-specified linear mixed-effects model with masked central reading.
What it changes
In earlier registered studies this readout appeared as a secondary endpoint or as an inclusion threshold. A trial designed around it on its own is a signal about how much confidence the field now places in the measurement, not about nicotinamide.
The same registry record names a limit of OCT thickness in established atrophy
NADIR screens on "macular GCIPL and peripapillary RNFL above device-specific SD-OCT floor effect in the study eye". The criterion states that a floor exists and that it is device-specific. The registry gives no numeric value for it.
What it changes
Retinal layer thickness measured by OCT does not fall to zero as ganglion cells are lost. It approaches a floor set by remaining non-neuronal tissue and by how the device segments the image, below which further axonal loss stops registering. The consequence runs in the flattering direction: a reading can suggest more surviving tissue than there is. It matters most in long-standing atrophy, which is exactly where the measurement is most often wanted.
No new PTEN structure has been deposited in seven consecutive weekly checks
A standing watch on the Protein Data Bank for new PTEN entries has returned nothing new across seven consecutive runs. The count of known structures stands at 28.
What it changes
Structure-based work on PTEN is still resting on the same set of depositions it has rested on for years. Anyone waiting for a new conformation, a cryptic pocket or a co-crystal to change the picture is, as of this date, still waiting.
Educational content based on published research. Not medical advice, and not intended to diagnose, treat, cure or prevent any disease. See editorial standards.